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SignaturePLUS™ enables researchers to take full advantage of Aushon's custom multiplex biomarker platform, which was recently validated in both Phase II and Phase III clinical trials.
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"We are currently designing clinical studies with Aushon's protein arrays incorporated for biomarker design and/or validation… with performance comparable to or better than ELISA in our studies." John Heymach, M.D., Ph.D., The University of Texas MD Anderson Cancer Center
Engineered for simple, out-of-the-box setup, the SignaturePLUS™ system offers incredible performance in a sleek, compact design that uses less than 2 feet of bench space. It features an integrated iPad® touch screen user interface and an embedded MacMini® computer, eliminating the need for separate, bulky components that take up valuable bench space.
SignaturePLUS™ is designed to capture a series of images, offering an improved broader dynamic range of assay quantification. Rapid imaging (typically <2 minutes per plate) and a fixed-focus setting – so no focus adjustments are required from one image to the next – make it easily shared by multiple users. Plus, automated calculations of image time make the instrument incredibly easy to use.
- Complete System: Imager (integrated with embedded Mac mini computer and iPad™ user interface), and array analysis software
- Performance: Improved sensitivity and dynamic range
- Fast: Typically generates 16-bit images in <2 minutes
- User-friendly: Integrated touch screen user interface for image capture and storage; Fixed-focus setting and automatic calculation of optimal image times
- Accuracy: Customized array software locates each spot in the image, measures density values and calculates pg/ml values for unknown samples from standard curves. Spot location and analysis is automatic and rapid. Providing nearly immediate access to measured sample concentrations.
- Quality: Custom, high resolution camera/lens for improved image quality and more consistent results
- Productivity: Image acquisition can take place at the bench, analysis at desk – freeing the imager for other users or to run more plates.
- Secure: Images can be archived for a permanent record of raw experimental data
- Set-up: Simple, fast, out-of-the-box installation – ready to use with minimal instruction
- Compact: Uses <2 sq.ft. of bench space; All components integrated with embedded MacMini and iPad user interface, eliminating need for separate system components
- Maintenance-free: Unlike fluidic array analysis systems, no daily, weekly or monthly maintenance is required
Imager Specifications
- Dimensions: 11” wide x 14 ¾” high x 24” deep
- Type of CCD: Front-illuminated
- Single Exposure Data Acquisition: 16 bit
- Resolution: 2184 x 1472 pixels
- Pixel Size: 6.8 x 6.8 µm
- Single Exposure Dynamic Range: 65,000 grayscale
- Cooling: -23⁰C
- Electrical Configuration: 100-240 VAC/1.8 amperes/50-60 Hz
PROarray™ Analyst Software
PROarray™ Analyst Software is specifically designed to quickly and accurately locate and quantify each spot within each well. The software offers the flexibility to analyze both small and large protein arrays in a plate format. It has been customized to incorporate standard ELISA analysis features, including curve fitting, calculation of pg/ml values, mean values, %CV (coefficient of variation), SD (standard deviation), and % backfit for standards. The software organizes the final data output by analyte and by sample, based on user-defined assay templates, making the information much easier to process. A simple export to Excel allows for additional graphing, analysis and sharing of final data reports.
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Features:
- Expanded Dynamic Range: Multiple exposures are used to form an expanded dynamic range curve to improve the measurement of low level samples while preventing the high level samples from reaching saturation levels.
- Accurate: Optimized for accurate analysis of quantitative protein arrays.
- Easy to Use: Standard protocols are easily created and saved. Auto spot location, alignment and measurement make image analysis fast and simple.
- Nearly Instantaneous Recalculation of Curve Fit and Sample Measurement: Provides immediate response to the removal of outliers
- Color Heat Map and Gray Scale Options: Selectable image viewing and manipulation options
- Internal Database: Provides rapid recall of standard and stored protocols.
- Consistent: Mathematical algorithms and standard ELISA analysis formulas ensure reproducible spot-finding, spot measurement, and analysis.
- Convenient: The software organizes the final data output by analyte and by sample based on user-defined assay templates, making the information much easier to process.
Click here for more information on How the Software Works
For more information, please email us at sales@aushon.com, or contact your Aushon Account Representative at 978-436-6464
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